The integrated stress response is activated in the salivary glands of Sjögren’s syndrome patients

The integrated stress response is activated in the salivary glands of Sjögren’s syndrome patients

IntroductionPrimary Sjögren’s syndrome (SS) is an autoimmune exocrinopathy that affects the structure and function of salivary and lachrymal glands. Labial salivary gland (LSG) acinar cells from SS patients lose cellular homeostasis and experience endoplasmic reticulum and oxidative stress. The inte...

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Bibliographic Details
Main Authors: Patricia Carvajal, Verónica Bahamondes, Daniela Jara, Isabel Castro, Soledad Matus, Sergio Aguilera, Claudio Molina, Sergio González, Marcela Hermoso, María-José Barrera, María-Julieta González
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Medicine
Subjects:
Sjögren’s syndrome
acinar cells
integrated stress response
salivary glands
ATF4
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1118703/full

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https://www.frontiersin.org/articles/10.3389/fmed.2023.1118703/full

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