hsa-miR-3177-5p and hsa-miR-3178 Inhibit 5-HT1A Expression by Binding the 3′-UTR Region in vitro

hsa-miR-3177-5p and hsa-miR-3178 Inhibit 5-HT1A Expression by Binding the 3′-UTR Region in vitro

Abnormal expression of the 5-HT1A receptor, which is encoded by the HTR1A gene, leads to susceptibilities to neuropsychiatric disorders such as depression, anxiety, and schizophrenia. miRNAs regulate gene expression by recognizing the 3′-UTR region of mRNA. This study evaluated the miRNAs that might...

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Bibliographic Details
Main Authors: Xue Wu, Mei Ding, Yi Liu, Xi Xia, Feng-ling Xu, Jun Yao, Bao-jie Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
HTR1A gene
5-HT1A receptor
hsa-miR-3177-5p
hsa-miR-3178
neuropsychiatric disorders
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00013/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00013/full

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