Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34

Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34

Biosynthesis of melatonin by cholangiocytes is essential for maintaining the function of biliary epithelium. However, this cytoprotective mechanism appears to be impaired in primary biliary cholangitis (PBC). MiR-132 has emerged as a mediator of inflammation in chronic liver diseases. The effect of...

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Bibliographic Details
Main Authors: Ewa Ostrycharz, Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Jesus M. Banales, Piotr Milkiewicz, Malgorzata Milkiewicz
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
primary biliary cholangitis
micro RNA
oxidative stress
apoptosis
Online Access:https://www.mdpi.com/1422-0067/21/24/9667

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https://www.mdpi.com/1422-0067/21/24/9667

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