CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment

CXCR4 and CXCR7 Signaling Pathways: A Focus on the Cross-Talk Between Cancer Cells and Tumor Microenvironment

The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers. They play a key role in the tumor/tumor microenvironment (TME) promoting tumor progression, targeting cell proliferation and migration, while...

Full description

Bibliographic Details
Main Authors: Sara Santagata, Caterina Ieranò, Anna Maria Trotta, Anna Capiluongo, Federica Auletta, Giuseppe Guardascione, Stefania Scala
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
CXCR4
CXCR7
tumor microenvironment
immune cells
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.591386/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.591386/full

Similar Items