Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension

Effects of ATRAP in Renal Proximal Tubules on Angiotensin‐Dependent Hypertension

Background We have previously shown that ATRAP (angiotensin II receptor–associated protein; Agtrap) interacts with AT1R (angiotensin II type 1 receptor) and promotes constitutive internalization of AT1R so as to inhibit hyperactivation of its downstream signaling. In response to angiotensin II, syst...

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Bibliographic Details
Main Authors: Sho Kinguchi, Hiromichi Wakui, Kengo Azushima, Kotaro Haruhara, Tomoyuki Koguchi, Kohji Ohki, Kazushi Uneda, Miyuki Matsuda, Sona Haku, Takahiro Yamaji, Takayuki Yamada, Ryu Kobayashi, Shintaro Minegishi, Tomoaki Ishigami, Akio Yamashita, Tetsuya Fujikawa, Kouichi Tamura
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
hypertension
kidney
renin–angiotensin system
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012395

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.012395

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