ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease. As such, they regulate cancer cell invasion, dissemination and metastasis of solid tumors. In addition, their expression is associated...

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Bibliographic Details
Main Authors: Steven Goossens, Jueqiong Wang, Cedric S. Tremblay, Jelle De Medts, Sara T’Sas, Thao Nguyen, Jesslyn Saw, Katharina Haigh, David J. Curtis, Pieter Van Vlierberghe, Geert Berx, Tom Taghon, Jody J. Haigh
Format: Article
Language:English
Published: Ferrata Storti Foundation 2019-08-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9009

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https://haematologica.org/article/view/9009

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