Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

Identification of hub molecules of FUS-ALS by Bayesian gene regulatory network analysis of iPSC model: iBRN

Summary: Fused in sarcoma/translated in liposarcoma (FUS) is a causative gene of amyotrophic lateral sclerosis (ALS). Mutated FUS causes accumulation of DNA damage and cytosolic stress granule (SG) formation, thereby motor neuron (MN) death. However, key molecular aetiology remains unclear. Here, we...

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Bibliographic Details
Main Authors: Masahiro Nogami, Mitsuru Ishikawa, Atsushi Doi, Osamu Sano, Takefumi Sone, Tetsuya Akiyama, Masashi Aoki, Atsushi Nakanishi, Kazuhiro Ogi, Masato Yano, Hideyuki Okano
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Induced pluripotent stem cell
Bayesian gene regulatory network analysis based on iPSC-derived cell model (iBRN)
Amyotrophic lateral sclerosis (ALS)
Fused in sarcoma/translated in liposarcoma (FUS)
DNA damage response (DDR)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001133

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http://www.sciencedirect.com/science/article/pii/S0969996121001133

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