Label-Free Imaging of Solid-Phase Peptide Synthesis Products and Their Modifications Tethered in Microspots Using Time-of-Flight Secondary Ion Mass Spectrometry

Label-Free Imaging of Solid-Phase Peptide Synthesis Products and Their Modifications Tethered in Microspots Using Time-of-Flight Secondary Ion Mass Spectrometry

Time-of-flight secondary ion mass spectrometry is used to analyze solid-phase synthesis products in 60 µm spots of high-density peptide arrays. As a result, a table of specific fragments for the individual detection of amino acids and their side chain protecting groups within peptides is compiled. T...

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Bibliographic Details
Main Authors: Dimitry Schmidt, Josef Maier, Hubert Bernauer, Alexander Nesterov-Mueller
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
imaging of chemical reactions
high-density peptide arrays
time-of-flight secondary ion mass spectrometry
Online Access:https://www.mdpi.com/1422-0067/24/21/15945

Internet

https://www.mdpi.com/1422-0067/24/21/15945

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