Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with <i>Closo</i>-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Tumor Cell-Specific 2′-Fluoro RNA Aptamer Conjugated with <i>Closo</i>-Dodecaborate as A Potential Agent for Boron Neutron Capture Therapy

Boron neutron capture therapy (BNCT) is a binary radiotherapeutic approach to the treatment of malignant tumors, especially glioblastoma, the most frequent and incurable brain tumor. For successful BNCT, a boron-containing therapeutic agent should provide selective and effective accumulation of <...

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Bibliographic Details
Main Authors: Mariya A. Vorobyeva, Maya A. Dymova, Darya S. Novopashina, Elena V. Kuligina, Valentina V. Timoshenko, Iaroslav A. Kolesnikov, Sergey Yu. Taskaev, Vladimir A. Richter, Alya G. Venyaminova
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
cell-specific aptamers
human glioblastoma cells
boron clusters
boron neutron capture therapy
cancer treatment
drug delivery
Online Access:https://www.mdpi.com/1422-0067/22/14/7326

Internet

https://www.mdpi.com/1422-0067/22/14/7326

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