The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases

The giant E3 ligase HUWE1 is linked to tumorigenesis, spermatogenesis, intellectual disability, and inflammatory diseases

E3 ubiquitin ligases determine the substrate specificity and catalyze the ubiquitination of lysine residues. HUWE1 is a catalytic HECT domain-containing giant E3 ligase that contains a substrate-binding ring structure, and mediates the ubiquitination of more than 40 diverse substrates. HUWE1 serves...

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Bibliographic Details
Main Authors: Lu Qi, Xiaoqing Xu, Xiaopeng Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HUWE1
ubiquitination
tumorigenesis
DNA damage response
inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.905906/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.905906/full

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