Diabetic Hearts Exhibit Global DNA Hypermethylation That Alter the Mitochondrial Functional Genes to Enhance the Sensitivity of the Heart to Ischemia Reperfusion Injury

Diabetic Hearts Exhibit Global DNA Hypermethylation That Alter the Mitochondrial Functional Genes to Enhance the Sensitivity of the Heart to Ischemia Reperfusion Injury

A recent study has shown that DNA hypermethylation can promote ischemia reperfusion (I/R) injury by regulating the mitochondrial function. Diabetes mellitus (DM) is reported to induce DNA hypermethylation, but whether this prior DNA methylation in DM I/R heart inflicts a beneficial or detrimental ef...

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Bibliographic Details
Main Authors: Sri Rahavi Boovarahan, David Raj Chellappan, Nemat Ali, Abdullah F. AlAsmari, Mohammad Waseem, Abdullah Saad Alabdulrahim, Ziyad Ali Alzahrani, Gino A. Kurian
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
diabetes
ischemia reperfusion
mitochondria
mRNA expression
DNA methylation
Online Access:https://www.mdpi.com/2227-9059/10/12/3065

Internet

https://www.mdpi.com/2227-9059/10/12/3065

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