The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

The transcription factor BACH1 is a potential therapeutic target for a variety of chronic conditions linked to oxidative stress and inflammation, as well as cancer metastasis. However, only a few BACH1 degraders/inhibitors have been described. BACH1 is a transcriptional repressor of heme oxygenase 1...

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Bibliographic Details
Main Authors: Laura Casares, Rita Moreno, Kevin X. Ali, Maureen Higgins, Sharadha Dayalan Naidu, Graham Neill, Lena Cassin, Anders E. Kiib, Esben B. Svenningsen, Alberto Minassi, Tadashi Honda, Thomas B. Poulsen, Clotilde Wiel, Volkan I. Sayin, Albena T. Dinkova-Kostova, David Olagnier, Laureano de la Vega
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Redox Biology
Subjects:
BACH1
HMOX1
CDDO
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722000635

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http://www.sciencedirect.com/science/article/pii/S2213231722000635

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