Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth
Abstract The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1 depletion caused a reduction in the EGFR...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-11-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-021-00367-2 |