Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

Summary: In mammals, nicotinamide (NAM) is the primary NAD precursor available in circulation, a signaling molecule, and a precursor for methyl-nicotinamide (M-NAM) synthesis. However, our knowledge about how the body regulates tissue NAM levels is still limited. Here we demonstrate that dietary vit...

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Dettagli Bibliografici
Autori principali: Julianna D. Zeidler, Claudia C.S. Chini, Karina S. Kanamori, Sonu Kashyap, Jair M. Espindola-Netto, Katie Thompson, Gina Warner, Fernanda S. Cabral, Thais R. Peclat, Lilian Sales Gomez, Sierra A. Lopez, Miles K. Wandersee, Renee A. Schoon, Kimberly Reid, Keir Menzies, Felipe Beckedorff, Joel M. Reid, Sebastian Brachs, Ralph G. Meyer, Mirella L. Meyer-Ficca, Eduardo Nunes Chini
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2022-11-01
Serie:iScience
Soggetti:
Biological sciences
Biochemistry
Molecular biology
Immunology
Accesso online:http://www.sciencedirect.com/science/article/pii/S2589004222017035

Accesso online

http://www.sciencedirect.com/science/article/pii/S2589004222017035

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