Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability.

The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis. Overexpression of EVI1 in acute myeloid leukaemia (AML) is frequently associated with 3q26 rearrangements and confers extremely poor prognosis. EVI1 mediates tra...

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Bibliographic Details
Main Authors: Daniel J White, Richard D Unwin, Eric Bindels, Andrew Pierce, Hsiang-Ying Teng, Joanne Muter, Brigit Greystoke, Tim D Somerville, John Griffiths, Simon Lovell, Tim C P Somervaille, Ruud Delwel, Anthony D Whetton, Stefan Meyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3680417?pdf=render

Internet

http://europepmc.org/articles/PMC3680417?pdf=render

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