Antioxidant Polyphenols of <i>Antirhea borbonica</i> Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke

Antioxidant Polyphenols of <i>Antirhea borbonica</i> Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke

Metabolic disorders related to obesity and type 2 diabetes are associated with aggravated cerebrovascular damages during stroke. In particular, hyperglycemia alters redox and inflammatory status, leading to cerebral endothelial cell dysfunction, blood–brain barrier (BBB) disruption and brain homeost...

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Bibliographic Details
Main Authors: Janice Taïlé, Matthieu Bringart, Cynthia Planesse, Jessica Patché, Philippe Rondeau, Bryan Veeren, Patricia Clerc, Anne Gauvin-Bialecki, Steeve Bourane, Olivier Meilhac, David Couret, Marie-Paule Gonthier
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Antioxidants
Subjects:
stroke
obesity
hyperglycemia
inflammation
oxidative stress
antioxidant polyphenols
Online Access:https://www.mdpi.com/2076-3921/11/5/858

Internet

https://www.mdpi.com/2076-3921/11/5/858

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