KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

KSR2-14–3-3ζ complex serves as a biomarker and potential therapeutic target in sorafenib-resistant hepatocellular carcinoma

Abstract Background Kinase suppressor of Ras 2 (KSR2) is a regulator of MAPK signaling that is overactivated in most hepatocellular carcinoma (HCC). We sought to determine the role of KSR2 in HCC pathogenesis. Methods We tested the level of KSR2 in HCC tissues and cell lines by tissue microarray, qP...

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Bibliographic Details
Main Authors: Chao Gao, Si-wei Wang, Jia-cheng Lu, Xiao-qiang Chai, Yuan-cheng Li, Peng-fei Zhang, Xiao-yong Huang, Jia-bin Cai, Yi-min Zheng, Xiao-jun Guo, Guo-ming Shi, Ai-wu Ke, Jia Fan
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Biomarker Research
Subjects:
Hepatocellular carcinoma
KSR2
14–3-3ζ
MAPK pathway
Sorafenib
Online Access:https://doi.org/10.1186/s40364-022-00361-9

Internet

https://doi.org/10.1186/s40364-022-00361-9

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