KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.

KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.

Homologous recombination and non-homologous end joining are two major DNA double-strand-break repair pathways. While HR-mediated repair requires a homologous sequence as the guiding template to restore the damage site precisely, NHEJ-mediated repair ligates the DNA lesion directly and increases the...

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Bibliographic Details
Main Authors: Yi-Hui Lin, Jian Yuan, Huadong Pei, Tongzheng Liu, David K Ann, Zhenkun Lou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4408008?pdf=render

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http://europepmc.org/articles/PMC4408008?pdf=render

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