The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating...

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Bibliographic Details
Main Authors: Zuyao Chen, Xiaolin Zhong, Min Xia, Jing Zhong
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
YTHDF1
N6-methyladenosine
m6A
protein translation
mRNA stability
tumor biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002663

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http://www.sciencedirect.com/science/article/pii/S2162253121002663

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