The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253121002663 |
| _version_ | 1819040154919108608 |
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| author | Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong |
| author_facet | Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong |
| author_sort | Zuyao Chen |
| collection | DOAJ |
| description | YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases. |
| first_indexed | 2024-12-21T09:04:36Z |
| format | Article |
| id | doaj.art-142ccd92499b4b4d8c3601d6ecd4dc60 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-21T09:04:36Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-142ccd92499b4b4d8c3601d6ecd4dc602022-12-21T19:09:23ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-12-012612701279The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseasesZuyao Chen0Xiaolin Zhong1Min Xia2Jing Zhong3Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; Department of Otorhinolaryngology, The First Affiliated Hospital, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, ChinaHengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, ChinaHengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, ChinaHengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China; Corresponding author: Jing Zhong, The First Affiliated Hospital, Institute Center of Clinical Medicine, Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China.YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.http://www.sciencedirect.com/science/article/pii/S2162253121002663YTHDF1N6-methyladenosinem6Aprotein translationmRNA stabilitytumor biology |
| spellingShingle | Zuyao Chen Xiaolin Zhong Min Xia Jing Zhong The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases Molecular Therapy: Nucleic Acids YTHDF1 N6-methyladenosine m6A protein translation mRNA stability tumor biology |
| title | The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases |
| title_full | The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases |
| title_fullStr | The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases |
| title_full_unstemmed | The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases |
| title_short | The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases |
| title_sort | roles and mechanisms of the m6a reader protein ythdf1 in tumor biology and human diseases |
| topic | YTHDF1 N6-methyladenosine m6A protein translation mRNA stability tumor biology |
| url | http://www.sciencedirect.com/science/article/pii/S2162253121002663 |
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