De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance

Abstract Background Gene-fusion or chimeric transcripts have been implicated in the onset and progression of a variety of cancers. Massively parallel RNA sequencing (RNA-Seq) of the cellular transcriptome is a promising approach for the identification of chimeric transcripts of potential functional...

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Bibliographic Details
Main Authors: Vinay K. Mittal, John F. McDonald
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Medical Genomics
Subjects:
Breast cancer
Transcriptome
Fusion-gene
Chimeric transcripts
de novo transcript assembly
Online Access:http://link.springer.com/article/10.1186/s12920-017-0289-7

Internet

http://link.springer.com/article/10.1186/s12920-017-0289-7

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