Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

Stereoselective Covalent Adduct Formation of Acyl Glucuronide Metabolite of Nonsteroidal Anti-Inflammatory Drugs with UDP-Glucuronosyltransferase

A reactive metabolite of nonsteroidal anti-inflammatory drugs (NSAIDs), acyl-β-D-glucuronide (AG), covalently binds to endogenous proteins. The covalent adduct formation of NSAIDs-AG may lead to the dysfunction of target proteins. Therefore, it is important to clarify the detailed characterization o...

Full description

Bibliographic Details
Main Authors: Atsushi Kawase, Rio Yamashita, Tsubasa Yoshizato, Mashiro Yoshikawa, Hiroaki Shimada, Masahiro Iwaki
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
NSAIDs
glucuronidation
glucuronide
stereoselective
liver injury
covalent adduct
Online Access:https://www.mdpi.com/1422-0067/23/9/4724

Internet

https://www.mdpi.com/1422-0067/23/9/4724

Similar Items