ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells

ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells

The mitogen-activated protein kinase (MAPK)/ERK and phosphatidylinositol-3 kinase (PI3K)/AKT pathways are dysregulated in various human cancers, including pancreatic ductal adenocarcinoma (PDAC), which has a very poor prognosis due to its lack of efficient therapies. We have previously identified AC...

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Bibliographic Details
Main Authors: Golam Iftakhar Khandakar, Ryosuke Satoh, Teruaki Takasaki, Kana Fujitani, Genzoh Tanabe, Kazuko Sakai, Kazuto Nishio, Reiko Sugiura
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
pancreatic cancer
ACAGT-007a (GT-7)
ERK MAPK
apoptosis
AKT signaling
KRAS
Online Access:https://www.mdpi.com/2073-4409/11/4/702

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https://www.mdpi.com/2073-4409/11/4/702

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