LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque

LDL-Based Lipid Nanoparticle Derived for Blood Plasma Accumulates Preferentially in Atherosclerotic Plaque

Apolipoprotein-based drug delivery is a promising approach to develop safe nanoparticles capable of targeted drug delivery for various diseases. In this work, we have synthesized a lipid-based nanoparticle (NPs) that we have called “Aposomes” presenting native apolipoprotein B-100 (apoB-100), the pr...

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Bibliographic Details
Main Authors: Christian A. Boada, Assaf Zinger, Scott Rohen, Jonathan O. Martinez, Michael Evangelopoulos, Roberto Molinaro, Madeleine Lu, Ramiro Alejandro Villarreal-Leal, Federica Giordano, Manuela Sushnitha, Enrica De Rosa, Jens B. Simonsen, Sergey Shevkoplyas, Francesca Taraballi, Ennio Tasciotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
LDL
Apolipoprotein
Rapamycin
Liposome
Nanoparticle
Drug Delivery
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.794676/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.794676/full

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