Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid

Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid

Here, using a mouse model, the authors report a previously undescribed role for medium-chain acyl-CoA dehydrogenase in host metabolism of gut microbiota metabolites, and show that circulating compounds, including the abundant organic acid hippurate, depend on host-microbe co-metabolism of phenylalan...

Full description

Bibliographic Details
Main Authors: Kali M. Pruss, Haoqing Chen, Yuanyuan Liu, William Van Treuren, Steven K. Higginbottom, John B. Jarman, Curt R. Fischer, Justin Mak, Beverly Wong, Tina M. Cowan, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36138-3

Internet

https://doi.org/10.1038/s41467-023-36138-3

Similar Items