The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway

The Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway

The imbalance between the GABA-mediated inhibition and the glutamate-mediated excitation is the primary pathological mechanism of epilepsy. GABAergic and glutamatergic neurotransmission have become the most important targets for controlling epilepsy. Ginsenoside compound K (GCK) is a main metabolic...

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Bibliographic Details
Main Authors: Xiangchang Zeng, Kai Hu, Lulu Chen, Luping Zhou, Wei Luo, Chaopeng Li, Wenjing Zong, Siyu Chen, Qing Gao, Guirong Zeng, Dejian Jiang, Xiaohui Li, Honghao Zhou, Dong-sheng Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
ginsenoside compound K
epilepsy
neurotransmitters
GABAARα1
KCC2
NKCC1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01020/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01020/full

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