Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury

Damage-associated molecular patterns and fibrinolysis perturbation are associated with lethal outcomes in traumatic injury

Abstract Background Upon cellular injury, damage-associated molecular patterns (DAMPs) are released into the extracellular space and evoke proinflammatory and prothrombotic responses in animal models of sterile inflammation. However, in clinical settings, the dynamics of DAMP levels after trauma and...

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Bibliographic Details
Main Authors: Kenshin Shimono, Takashi Ito, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Hirokazu Onishi, Hideaki Yoshihara, Ikuro Maruyama, Yasuyuki Kakihana
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Thrombosis Journal
Subjects:
Damage-associated molecular patterns (DAMPs)
Trauma-induced coagulopathy
Histone H3
Plasmin-α2-PI complex (PIC)
Plasminogen activator inhibitor-1 (PAI-1)
Online Access:https://doi.org/10.1186/s12959-023-00536-w

Internet

https://doi.org/10.1186/s12959-023-00536-w

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