Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

Paternal obesity has been implicated in adult-onset metabolic disease in offspring. However, the molecular mechanisms driving these paternal effects and the developmental processes involved remain poorly understood. One underexplored possibility is the role of paternally induced effects on placenta...

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Bibliographic Details
Main Authors: Anne-Sophie Pepin, Patrycja A Jazwiec, Vanessa Dumeaux, Deborah M Sloboda, Sarah Kimmins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/83288