ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors

ITC-6102RO, a novel B7-H3 antibody-drug conjugate, exhibits potent therapeutic effects against B7-H3 expressing solid tumors

Abstract Background The B7-H3 protein, encoded by the CD276 gene, is a member of the B7 family of proteins and a transmembrane glycoprotein. It is highly expressed in various solid tumors, such as lung and breast cancer, and has been associated with limited expression in normal tissues and poor clin...

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Bibliographic Details
Main Authors: Seol Hwa Shin, Eun Jin Ju, Jin Park, Eun Jung Ko, Mi Ri Kwon, Hye Won Lee, Ga Won Son, Yun-Yong Park, Yeon Joo Kim, Si Yeol Song, Sangkwang Lee, Beom Seok Seo, Jin-A Song, Sangbin Lim, Doohwan Jung, Sunyoung Kim, Hyangsook Lee, Seok Soon Park, Seong-Yun Jeong, Eun Kyung Choi
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cancer Cell International
Subjects:
Antibody-drug conjugate (ADC)
B7-H3
Ortho hydroxy-protected aryl sulfate (OHPAS)-linkers
Patient-derived xenograft (PDX)
Online Access:https://doi.org/10.1186/s12935-023-02991-x

Internet

https://doi.org/10.1186/s12935-023-02991-x

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