HIV reservoirs are dominated by genetically younger and clonally enriched proviruses

HIV reservoirs are dominated by genetically younger and clonally enriched proviruses

ABSTRACTIn order to cure human immunodeficiency virus (HIV), we need to better understand the within-host evolutionary origins of the small reservoir of genome-intact proviruses that persist within infected cells during antiretroviral therapy (ART). Most prior studies on reservoir evolutionary dynam...

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Bibliographic Details
Main Authors: Natalie N. Kinloch, Aniqa Shahid, Winnie Dong, Don Kirkby, Bradley R. Jones, Charlotte J. Beelen, Daniel MacMillan, Guinevere Q. Lee, Talia M. Mota, Hanwei Sudderuddin, Evan Barad, Marianne Harris, Chanson J. Brumme, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Zabrina L. Brumme
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
HIV reservoir
persistence
genomic integrity
molecular dating
proviral landscape
phylogenetics
Online Access:https://journals.asm.org/doi/10.1128/mbio.02417-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02417-23

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