β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice

β-secretase inhibition prevents structural spine plasticity deficits in AppNL-G-F mice

All clinical BACE1-inhibitor trials for the treatment of Alzheimer's Disease (AD) have failed due to insufficient efficacy or side effects like worsening of cognitive symptoms. However, the scientific evidence to date suggests that BACE1-inhibition could be an effective preventative measure if...

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Bibliographic Details
Main Authors: Tanja Blume, Severin Filser, Carmelo Sgobio, Finn Peters, Ulf Neumann, Derya Shimshek, Takashi Saito, Takaomi C. Saido, Matthias Brendel, Jochen Herms
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer's disease
dendritic spines
in vivo two-photon microscopy
BACE1-inhibition
APP knock-in
AppNL-G-F
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.909586/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.909586/full

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