A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method

Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent casting metho...

Full description

Bibliographic Details
Main Authors: Chetan Borkhataria, Hardik Chauhan, Bhargavi Mistry, Manisha Kalaria, Rachana Katbamana, Kalpesh Patel
Format: Article
Language:English
Published: Hindawi Limited 2024-01-01
Series:International Journal of Chemical Engineering
Online Access:http://dx.doi.org/10.1155/2024/8734695
_version_ 1797206022328156160
author Chetan Borkhataria
Hardik Chauhan
Bhargavi Mistry
Manisha Kalaria
Rachana Katbamana
Kalpesh Patel
author_facet Chetan Borkhataria
Hardik Chauhan
Bhargavi Mistry
Manisha Kalaria
Rachana Katbamana
Kalpesh Patel
author_sort Chetan Borkhataria
collection DOAJ
description Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent casting method using a spray drying method. Methods. The solvent casting method was used to screen polymers, PVP/VA S-630, PVP K30, Soluplus, PEG 4000, HPMC AS, and HPMC HP55, in 1 : 1 and 2 : 3 ratios and followed by spray drying after polymer selection. Results. The dissolution performance of the formulation improved with time. The optimum feed rate and feed concentration were found to have an impact on the flow properties and particle size of spray-dried formulations, and they were selected as independent variables in a 32 full factorial statistical design. The ANOVA and regression analysis suggest that the developed regression model has a significant overall fit to the data and can explain a substantial proportion of the variability in the dissolution at 10 minutes. The optimized batch was selected based on the decisive factors of minimum and maximum values of response variables. Overall, the optimized batch demonstrated improved characteristics in terms of percentage yield (32.81%), dissolution at 10 min (49.70%), and angle of repose at 31.42°. Conclusion. This study provides valuable insights into optimizing formulation strategies for preserving the amorphous state of drugs and contributes to the development of stable pharmaceutical formulations.
first_indexed 2024-04-24T09:00:24Z
format Article
id doaj.art-144a632841444a98a7375970c92f2a25
institution Directory Open Access Journal
issn 1687-8078
language English
last_indexed 2024-04-24T09:00:24Z
publishDate 2024-01-01
publisher Hindawi Limited
record_format Article
series International Journal of Chemical Engineering
spelling doaj.art-144a632841444a98a7375970c92f2a252024-04-16T00:00:03ZengHindawi LimitedInternational Journal of Chemical Engineering1687-80782024-01-01202410.1155/2024/8734695A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying MethodChetan Borkhataria0Hardik Chauhan1Bhargavi Mistry2Manisha Kalaria3Rachana Katbamana4Kalpesh Patel5B. K. Mody Government Pharmacy CollegeB. K. Mody Government Pharmacy CollegeSchool of PharmacyB. K. Mody Government Pharmacy CollegeB. K. Mody Government Pharmacy CollegeB. K. Mody Government Pharmacy CollegeBackground. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous solid dispersion after screening of polymers by solvent casting method using a spray drying method. Methods. The solvent casting method was used to screen polymers, PVP/VA S-630, PVP K30, Soluplus, PEG 4000, HPMC AS, and HPMC HP55, in 1 : 1 and 2 : 3 ratios and followed by spray drying after polymer selection. Results. The dissolution performance of the formulation improved with time. The optimum feed rate and feed concentration were found to have an impact on the flow properties and particle size of spray-dried formulations, and they were selected as independent variables in a 32 full factorial statistical design. The ANOVA and regression analysis suggest that the developed regression model has a significant overall fit to the data and can explain a substantial proportion of the variability in the dissolution at 10 minutes. The optimized batch was selected based on the decisive factors of minimum and maximum values of response variables. Overall, the optimized batch demonstrated improved characteristics in terms of percentage yield (32.81%), dissolution at 10 min (49.70%), and angle of repose at 31.42°. Conclusion. This study provides valuable insights into optimizing formulation strategies for preserving the amorphous state of drugs and contributes to the development of stable pharmaceutical formulations.http://dx.doi.org/10.1155/2024/8734695
spellingShingle Chetan Borkhataria
Hardik Chauhan
Bhargavi Mistry
Manisha Kalaria
Rachana Katbamana
Kalpesh Patel
A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
International Journal of Chemical Engineering
title A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
title_full A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
title_fullStr A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
title_full_unstemmed A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
title_short A Retrospective Analysis of Polymer Selection Using Solvent Casting: Formulation and DoE Optimization of the Amorphous Solid Dispersion of Amoxicillin Trihydrate by a Spray Drying Method
title_sort retrospective analysis of polymer selection using solvent casting formulation and doe optimization of the amorphous solid dispersion of amoxicillin trihydrate by a spray drying method
url http://dx.doi.org/10.1155/2024/8734695
work_keys_str_mv AT chetanborkhataria aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT hardikchauhan aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT bhargavimistry aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT manishakalaria aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT rachanakatbamana aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT kalpeshpatel aretrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT chetanborkhataria retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT hardikchauhan retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT bhargavimistry retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT manishakalaria retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT rachanakatbamana retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod
AT kalpeshpatel retrospectiveanalysisofpolymerselectionusingsolventcastingformulationanddoeoptimizationoftheamorphoussoliddispersionofamoxicillintrihydratebyaspraydryingmethod