The traditional chinese medicine monomer Ailanthone improves the therapeutic efficacy of anti-PD-L1 in melanoma cells by targeting c-Jun

The traditional chinese medicine monomer Ailanthone improves the therapeutic efficacy of anti-PD-L1 in melanoma cells by targeting c-Jun

Abstract Background C-Jun, a critical component of AP-1, exerts essential functions in various tumors, including melanoma, and is believed to be a druggable target for cancer therapy. Unfortunately, no effective c-Jun inhibitors are currently approved for clinical use. The advent of immune checkpoin...

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Bibliographic Details
Main Authors: Pian Yu, Hui Wei, Kaixuan Li, Shiguo Zhu, Jie Li, Chao Chen, Detian Zhang, Yayun Li, Lei Zhu, Xiaoqing Yi, Nian Liu, Panpan Liu, Shuang Zhao, Xiang Chen, Cong Peng
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Melanoma
Ailanthone
PD-L1
c-Jun
Treg
Tumor microenvironment
Online Access:https://doi.org/10.1186/s13046-022-02559-z

Internet

https://doi.org/10.1186/s13046-022-02559-z

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