Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Cepharanthine Blocks Presentation of Thyroid and Islet Peptides in a Novel Humanized Autoimmune Diabetes and Thyroiditis Mouse Model

Autoimmune polyglandular syndrome type 3 variant (APS3v) refers to an autoimmune condition in which both type 1 diabetes (T1D) and autoimmune thyroiditis (AITD) develop in the same individual. HLA-DR3 confers the strongest susceptibility to APS3v. Previously we reported a unique amino acid signature...

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Bibliographic Details
Main Authors: Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C. Faustino, Kookjoo Kim, Oliver B. Clarke, Hanxi Hou, Yaron Tomer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
autoimmune thyroiditis
type 1 diabetes
autoimmune polyglandular syndrome
cepharanthine
immune therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.796552/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.796552/full

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