Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events

Aβ-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events

Summary: Aβ bears homology to the CaMKII regulatory domain, and peptides derived from this domain can bind and disrupt the CaMKII holoenzyme, suggesting that Aβ could have a similar effect. Notably, Aβ impairs the synaptic CaMKII accumulation that is mediated by GluN2B binding, which requires CaMKII...

Full description

Bibliographic Details
Main Authors: Carolyn Nicole Brown, Nicole L. Rumian, Jonathan E. Tullis, Steven J. Coultrap, K. Ulrich Bayer
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222006393

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222006393

Similar Items