Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice.

Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice.

BACKGROUND: Continuous support from follicular CD4(+) T helper (Tfh) cells drives germinal center (GC) responses, which last for several weeks to produce high affinity memory B cells and plasma cells. In autoimmune Sle1 and NZB/W F1 mice, elevated numbers of Tfh cells persist, promoting the expansio...

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Bibliographic Details
Main Authors: Isharat Yusuf, Jessica Stern, Tom M McCaughtry, Sandra Gallagher, Hong Sun, Changshou Gao, Thomas Tedder, Gianluca Carlesso, Laura Carter, Ronald Herbst, Yue Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4125140?pdf=render

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http://europepmc.org/articles/PMC4125140?pdf=render

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