Preclinical evaluation and first in human study of Al18F radiolabeled ODAP-urea-based PSMA targeting ligand for PET imaging of prostate cancer

Preclinical evaluation and first in human study of Al18F radiolabeled ODAP-urea-based PSMA targeting ligand for PET imaging of prostate cancer

PurposeThis study aimed to introduce a novel [18F]AlF-labeled ODAP-Urea-based Prostate-specific membrane antigen (PSMA) probe, named [18F]AlF-PSMA-137, which was derived from the successful modification of glutamate-like functional group. The preclinically physical and biological characteristics of...

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Bibliographic Details
Main Authors: Ya’nan Ren, Chen Liu, Teli Liu, Xiaojiang Duan, Qian Zhang, Jiayue Liu, Pei Wang, Qian Guo, Xing Yang, Peng Du, Hua Zhu, Zhi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
PSMA
oxalyldiaminopropionic acid-urea (ODAP-Urea) ligand
prostate cancer
[18F]AlF2+
clinical translational
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1030187/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1030187/full

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