Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.

Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.

Mycobacterium tuberculosis DNA gyrase, an indispensable nanomachine involved in the regulation of DNA topology, is the only type II topoisomerase present in this organism and is hence the sole target for quinolone action, a crucial drug active against multidrug-resistant tuberculosis. To understand...

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Bibliographic Details
Main Authors: Jérémie Piton, Stéphanie Petrella, Marc Delarue, Gwénaëlle André-Leroux, Vincent Jarlier, Alexandra Aubry, Claudine Mayer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2923608?pdf=render

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http://europepmc.org/articles/PMC2923608?pdf=render

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