The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss

The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss

Mutations in five unconventional myosin genes have been associated with genetic hearing loss (HL). These genes encode the motor proteins myosin IA, IIIA, VI, VIIA and XVA. To date, most mutations in myosin genes have been found in the Caucasian population. In addition, only a few functional studies...

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Bibliographic Details
Main Authors: Tae-Jun Kwon, Se-Kyung Oh, Hong-Joon Park, Osamu Sato, Hanka Venselaar, Soo Young Choi, SungHee Kim, Kyu-Yup Lee, Jinwoong Bok, Sang-Heun Lee, Gert Vriend, Mitsuo Ikebe, Un-Kyung Kim, Jae Young Choi
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
myosin
mutation
atpase
protein structure
gene
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140107

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140107

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