Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers

Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers

The multifunctional protein Y-box binding protein-1 (YB-1) regulates all the so far described cancer hallmarks including cell proliferation and survival. The MAPK/ERK and PI3K/Akt pathways are also the major pathways involved in cell growth, proliferation, and survival, and are the frequently hypera...

Full description

Bibliographic Details
Main Authors: Aadhya Tiwari, Mari Iida, Corinna Kosnopfel, Mahyar Abbariki, Apostolos Menegakis, Birgit Fehrenbacher, Julia Maier, Martin Schaller, Sara Y. Brucker, Deric L. Wheeler, Paul M. Harari, Ulrich Rothbauer, Birgit Schittek, Daniel Zips, Mahmoud Toulany
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
triple negative breast cancer cells
KRAS
PTEN
PIK3CA
YB-1
MAPK/ERK
Online Access:https://www.mdpi.com/2072-6694/12/10/2795

Internet

https://www.mdpi.com/2072-6694/12/10/2795

Similar Items