Three <italic toggle="yes">Toxoplasma gondii</italic> Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

Three <italic toggle="yes">Toxoplasma gondii</italic> Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

ABSTRACT Upon invasion of Lewis rat macrophages, Toxoplasma rapidly induces programmed cell death (pyroptosis), which prevents Toxoplasma replication, possibly explaining the resistance of the Lewis rat to Toxoplasma. Using a chemical mutagenesis screen, we identified Toxoplasma mutants that no long...

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Bibliographic Details
Main Authors: Yifan Wang, Kimberly M. Cirelli, Patricio D. C. Barros, Lamba Omar Sangaré, Vincent Butty, Musa A. Hassan, Patricia Pesavento, Asli Mete, Jeroen P. J. Saeij
Format: Article
Language:English
Published: American Society for Microbiology 2019-02-01
Series:mBio
Subjects:
Dense granule proteins
macrophages
NLRP1 inflammasomes
pyroptosis
Toxoplasma gondii
Online Access:https://journals.asm.org/doi/10.1128/mBio.02388-18

Internet

https://journals.asm.org/doi/10.1128/mBio.02388-18

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