Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

Comparative Pharmacokinetics of a Dual Inhibitor of HIV-1, NBD-14189, in Rats and Dogs with a Proof-of-Concept Evaluation of Antiviral Potency in SCID-hu Mouse Model

We earlier reported substantial progress in designing gp120 antagonists. Notably, we discovered that NBD-14189 is not only the most active gp120 antagonist but also shows antiviral activity against HIV-1 Reverse Transcriptase (RT). We also confirmed its binding to HIV-1 RT by X-ray crystallography....

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Bibliographic Details
Main Authors: Cheryl A. Stoddart, Francesca Curreli, Stephen Horrigan, Andrea Altieri, Alexander V. Kurkin, Asim K. Debnath
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Viruses
Subjects:
human immunodeficiency virus type 1 (HIV-1)
HIV-1 gp120 antagonist
dual inhibitors
pharmacokinetics (PK)
bioavailability
SCID-hu mouse model
Online Access:https://www.mdpi.com/1999-4915/14/10/2268

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https://www.mdpi.com/1999-4915/14/10/2268

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