α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway

α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway

Abstract Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic dysfunction is linked to cognitive deficits in LBD. Here, we investigated the pathological impact of αSyn on hippoc...

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Main Authors: Marina I. Oliveira da Silva, Miguel Santejo, Isaac W. Babcock, Ana Magalhães, Laurie S. Minamide, Seok-Joon Won, Erika Castillo, Ellen Gerhardt, Christiane Fahlbusch, Raymond A. Swanson, Tiago F. Outeiro, Ricardo Taipa, Michael Ruff, James R. Bamburg, Márcia A. Liz
格式: 文件
语言:English
出版: Nature Publishing Group 2024-04-01
丛编:Cell Death and Disease
在线阅读:https://doi.org/10.1038/s41419-024-06630-9

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https://doi.org/10.1038/s41419-024-06630-9

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