Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway

Spermidine attenuates chondrocyte inflammation and cellular pyroptosis through the AhR/NF-κB axis and the NLRP3/caspase-1/GSDMD pathway

IntroductionOsteoarthritis (OA) is a prevalent chronic degenerative disease, marked by a complex interplay of mechanical stress, inflammation, and metabolic imbalances. Recent studies have highlighted the potential of spermidine (SPD), a naturally occurring polyamine known for its anti-inflammatory...

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Bibliographic Details
Main Authors: Xiaocheng Guo, Xinyuan Feng, Yue Yang, He Zhang, Lunhao Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
spermidine
osteoarthritis
aromatic hydrocarbon receptor
inflammation
pyroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462777/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462777/full

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