Hydrangea paniculata coumarins attenuate experimental membranous nephritis by bidirectional interactions with the gut microbiota

Abstract Coumarins isolated from Hydrangea paniculata (HP) had a renal protective effect in experimental membranous nephritis (MN), but the mechanisms are not clear. Currently, we investigate whether the modulation of gut dysbiosis by HP contributes to its renal protection. Experimental MN rats were...

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Bibliographic Details
Main Authors: Zhaojun Li, Xingguang Zhang, Haijie Wu, Zhiling Ma, Xikun Liu, Jie Ma, Dongming Zhang, Li Sheng, Xiaoguang Chen, Sen Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05581-9