Construction of a plasmid-free l-leucine overproducing Escherichia coli strain through reprogramming of the metabolic flux

Construction of a plasmid-free l-leucine overproducing Escherichia coli strain through reprogramming of the metabolic flux

Abstract Background l-Leucine is a high-value amino acid with promising applications in the medicine and feed industries. However, the complex metabolic network and intracellular redox imbalance in fermentative microbes limit their efficient biosynthesis of l-leucine. Results In this study, we appli...

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Bibliographic Details
Main Authors: Yanan Hao, Xuewei Pan, Guomin Li, Jiajia You, Hengwei Zhang, Sihan Yan, Meijuan Xu, Zhiming Rao
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
l-Leucine
Metabolic engineering
Redox cofactors
Dynamic regulation
Escherichia coli
Online Access:https://doi.org/10.1186/s13068-023-02397-x

Internet

https://doi.org/10.1186/s13068-023-02397-x

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