Gentiopicroside targeting AKT1 activates HIF-1α/VEGF axis promoting diabetic ulcer wound healing

BackgoundGentiopicroside (GSP) have been proven to accelerate the healing of diabetic ulcers (DU), but the underlying molecular mechanisms remain unclear. This study aims to explore the mechanism by which GSP accelerates the healing of DU.MethodThe targets of GSP were firstly predicted using the Sup...

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Bibliographic Details
Main Authors: Xinxia Wang, Mingyan Liu, Yao Wu, Jianguo Sun, Li Liu, Zheng Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1506499/full