Organic Anion Transporting Polypeptides 1B1 and 1B3 Play an Important Role in Uremic Toxin Handling and Drug-Uremic Toxin Interactions in the Liver

Organic Anion Transporting Polypeptides 1B1 and 1B3 Play an Important Role in Uremic Toxin Handling and Drug-Uremic Toxin Interactions in the Liver

PURPOSE. Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of drug-uremic toxin interactions on...

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Bibliographic Details
Main Authors: Toshihiro Sato, Hiroaki Yamaguchi, Takuma Kogawa, Takaaki Abe, Nariyasu Mano
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/22290

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https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/22290

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