Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit

Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit

The α9α10 nicotinic acetylcholine receptor (nAChR) plays a fundamental role in inner ear physiology. It mediates synaptic transmission between efferent olivocochlear fibers that descend from the brainstem and hair cells of the auditory sensory epithelium. The α9 and α10 subunits have undergone a dis...

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Bibliographic Details
Main Authors: Marcelo J. Moglie, Irina Marcovich, Jeremías Corradi, Agustín E. Carpaneto Freixas, Sofía Gallino, Paola V. Plazas, Cecilia Bouzat, Marcela Lipovsek, Ana Belén Elgoyhen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlea
nicotinic receptors
evolution
hearing
choline
acetylcholine
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.639720/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2021.639720/full

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