iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release

iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release

Multiple system atrophy of the parkinsonian type (MSA-P) is a rare, fatal neurodegenerative disease with sporadic onset. It is still unknown if MSA-P is a primary oligodendropathy or caused by neuronal pathophysiology leading to severe, α-synuclein-associated neurodegeneration, mainly in the striatu...

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Bibliographic Details
Main Authors: Lisa M. Henkel, Svenja Kankowski, Thiemo M. Moellenkamp, Nadine J. Smandzich, Sigrid Schwarz, Alessio Di Fonzo, Gudrun Göhring, Günter Höglinger, Florian Wegner
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
induced pluripotent stem cells (iPSCs)
striatal medium spiny neurons (MSNs)
multiple system atrophy (MSA)
α-synuclein
hypoexcitability
Online Access:https://www.mdpi.com/2073-4409/12/2/223

Internet

https://www.mdpi.com/2073-4409/12/2/223

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